Amisulpride Powder

Product Description

Amisulpride sold under the brand name Solian among others is an antipsychotic medication used to treat schizophrenia1 It is also used to treat dysthymia5 It is usually classed with the atypical antipsychotics Chemically it is a benzamide and like other benzamide antipsychotics such as sulpiride it is associated with a high risk of elevating blood levels of the lactation hormone prolactin thereby potentially causing the absence of the menstrual cycle breast milk secretion not related to breastfeeding impaired fertility impotence breast pain etc and a low risk relative to the typical antipsychotics of causing movement disorders678 It has also been found to be modestly more effective in treating schizophrenia than the typical antipsychotics7

Amisulpride is believed to work by reducing signalling via the dopamine D2 receptor In amisulprides case this is by blocking or antagonizing the receptor Amisulprides effectiveness in treating dysthymia and the negative symptoms of schizophrenia is believed to stem from its blockade of the presynaptic dopamine D2 receptors These presynaptic receptors regulate the release of dopamine into the synapse so by blocking them amisulpride increases dopamine concentrations in the synapse This increased dopamine concentration is theorized to act on dopamine D1 receptors to relieve depressive symptoms in dysthymia and the negative symptoms of schizophrenia5

It was introduced by SanofiAventis in the 1990s Its patent had expired by 2008 and hence generic formulations are now available9 It is marketed in all Englishspeaking countries except for Canada and the United States8 A New York City based company LB Pharmaceuticals has announced the development of a version of amisulpride specifically targeting the United States although it is unclear when that product would actually be on the market10 A poster presentation at ECNPclarification needed seems to suggest that this version of amisulpride known as LB102 displays the same binding to D2 D3 and 5HT7 that amisulpride does11